TTF1 Rabbit Monoclonal Antibody(ARB839)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
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Brand:
CAT.NO. : ARB6629
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Size:
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Product Details
Background
Thyroid transcription factor-1 (synonymes: Homeobox protein Nkx-2.1) is a 371 amino acid protein, 39 KDa, which belongs to the NKX homeobox transcription factor family. TTF-1 stimulate or repress transcription of particular genes by binding to their regulatory sequences. TTF-1 plays a role in regulating genes in the thyroid, lung and brain. Its molecular targets in the thyroid gland are thyroglobulin, thyroperoxidase and thyrotropin receptor. TTF-1 activates transcription of the genes encoding these proteins. In lung, TTF-1 promotes the transcription of the surfactant proteins A to D, and the Clara cell secretory protein. In brain, the molecular targets of TTF-1 are unknown. Besides being a tissue-specific transcription promoter in adult organs, TTF-1 has been suggested a role in morphogenesis and cytodifferentiation. Among thyroid neoplasms, TTF1 is seen in virtually all tumours of follicular derivation. In diagnostic pathology, TTF-1 is useful as marker for pulmonary adenocarcinoma and pulmonary neuroendocrine malignancy, including small cell lung carcinoma. It can be used to differentiate primary lung adenocarcinoma from metastasis of extrapulmonary origin.
Overview
| Target | TTF-1 |
| Host Species | rabbit monoclonal antibody |
| Molecular Weight | 39 kDa |
| Purity | ProA affinity purified IgG |
| Species Cross-reactivity | Human |
| Form | Liquid |
| Applications | IHC-P |
| Swissprot ID | P43699 |
| Immunogen | Synthetic peptide corresponding to residues within aa50-150 of TTF-1 |
| Storage Buffer | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
| Storage Conditions | -25°C to -18°C |
| Dilutions | IHC-P: 1:100-1:200 |
| Subcellular Location | Nucleus |
| Recommended Method | Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes |
Data
Immunohistochemical staining of human thyroid carcinoma tissue sections negative for TTF1 using TTF1 Rabbit Monoclonal Antibody (ARB839).
Immunohistochemical staining of human thyroid tissue sections negative for TTF1 using TTF1 Rabbit Monoclonal Antibody (ARB839).
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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