ZAP-70 Mouse Monoclonal Antibody(ARM909)
Key features and details
- Reactivity:Human
- Application:IHC,ELISA
- Host:Mouse
- Clonality:Monoclonal
- lsotype:IgG2a
- Target Name:ZAP-70
- Research use only.
-
Brand:
CAT.NO. : ARM6699
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Product Details
Background
ZAP70 (Zeta Chain Of T Cell Receptor Associated Protein Kinase 70) is a protein coding gene located on human chromosome 2q11.2. ZAP70 is also known as SRK, STD, TZK, STCD, IMD48, ADMIO2 and ZAP-70. The human ZAP70 gene encodes a 69872 Da protein containing 619 amino acids. The ZAP70 protein is biasedly expressed in lymph node, spleen and other tissues. Among its related pathways are NF-KappaB Family Pathway and TCR Signaling (Qiagen). ZAP70 is related to transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. SYK is an important paralog of ZAP70 gene. ZAP70 is associated with some diseases, including Immunodeficiency 48 and Autoimmune Disease, Multisystem, Infantile-Onset, 2.
Application
IHC: 1:50-1:200
Overview
|
Molecular Weight |
55,873 Da |
|
OMIM |
176947 |
|
3D Structure |
ModBase 3D Structure for P43403 |
|
Clonality |
Monoclonal |
|
Isotype |
IgG2a |
|
Host |
Mouse |
|
Species Reactivity |
Human |
|
Purity/Purification |
Purified |
|
Form/Format |
Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide |
Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of Human Lymph Node sections labeling ZAP-70 with ARM909.
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
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