ZEB1 Rabbit Monoclonal Antibody(ARA895)

Key features and details

Reactivity:Human
Application:IHC
Host:Rabbit
Clonality:Monoclonal
Target:ZEB1

Brand:

CAT.NO. : ARA6722

RMB Please choose

Size:

1mL

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Product Details

Background

Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene. ZEB1 (previously known as TCF8) encodes a zinc finger and homeodomain transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site. ZEB1 and its mammalian paralog ZEB2 belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors. ZEB1 protein has 7 zinc fingers and 1 homeodomain. The structure of the homeodomain is shown on the right. Mutations of the gene are linked to posterior polymorphous corneal dystrophy 3. ZEB1 downregulates E-cadherin and induces epithelial to mesenchymal transition in breast and other carcinomas A recent study suggested its contributing role in lung cancer invasiveness and metastasis development. Overexpression of ZEB1 has been identified as a potential risk factor for recurrence and poor prognosis in several types of cancers.

Application

Application	Dilution Ratio
IHC-P	1:100-1:1000

Overview

Immunogen	Recombinant protein within human ZEB1 aa 1-400 / 1,124
Species Reactivity	Human, Mouse, Rat
Molecular Weight	Predicted band size: 124 kDa
Conjugation	unconjugated
RRID	AB_3072554
Form	Liquid
Concentration	1ug/ul
Storage Buffer	PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide
Isotype	IgG
Purification Method	Protein A affinity purified