CD138 Rabbit Monoclonal Antibody(ARB889)
Datasheet
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
-
Brand:
CAT.NO. : ARB6681
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Product Details
Background
CD138, also designated syndecan - 1, is a member of the syndecan family of four transmembrane spanning proteins capable of binding to heparan sulfate and chondroitin sulfate molecules. The syndecans’ main functions are to control cell growth and differentiation as well as to maintain cell adhesion and cell migration. Under normal conditions CD138 is predominantly expressed on mature plasma cells and early pre - B cells, while other haematolymphoid cells are negative. Various types of epithelial cells are also CD138 positive. Squamous epithelial cells show strong membranous and some cytoplasmic staining, except for the mature superficial squamous epithelial cells which are unstained. Mature mesenchymal and neural tissues are not stained. Among haematolymphoid neoplasms, CD138 is expressed in practically all cases of plasma cell malignancies. Among nonhaematolymphoid neoplasms the expression of CD138 is found in various types of carcinoma. In the following, the large majority of cases is CD138 positive: skin squamous cell carcinoma and basal cell carcinoma, colorectal adenocarcinoma, cholangiocarcinoma, transitional cell carcinoma, endometrial adenocarcinoma, ductal and lobular breast carcinoma, hepatocellular carcinoma, renal cell carcinoma, and lung adenocarcinoma. CD138 is a very sensitive and specific marker for identification of plasma cells and plasma cell differentiation within haematolymphoid tissues in benign and neoplastic conditions.
Overview
| Target | CD138 |
| Host Species | rabbit monoclonal antibody |
| Molecular Weight | 32 kDa |
| Purity | ProA affinity purified IgG |
| Species Cross-reactivity | Human |
| Form | Liquid |
| Applications | IHC-P |
| Swissprot ID | P18827 |
| Immunogen | Synthetic peptide corresponding to CD138 residues within aa200-300 of CD138 |
| Storage Buffer | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
| Storage Conditions | -25°C to -18°C |
| Dilutions | IHC-P: 1:100-1:200 |
| Subcellular Location | Membrane |
| Recommended Method | Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes |
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:100 - 1:200 |
Data
Immunohistochemical staining of human tonsil tissue sections using CD138 Rabbit Monoclonal Antibody (ARB889).
Immunohistochemical staining of human plasmacytoma tissue sections using CD138 Rabbit Monoclonal Antibody (ARB889).
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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