MLH1 Mouse Monoclonal Antibody (IHC409)
Datasheet
Key features and details
- Reactivity:
- Application:
- Host:
- Clonality:
- lsotype:
- Target Name:
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Brand:
CAT.NO. : ARA1409
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Product Details
Background
MutL Homolog 1 (MLH1) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, as the MLH1 gene is frequently mutated in patients with this cancer. Studies have shown MLH1 to be deficient in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of Anti-MLH1 is optimized when paired in an IHC panel with MSH6, MSH2, and PMS2. Anti-MLH1 is useful in the detection of MLH1 in a number of normal and neoplastic tissues, and for identifying a loss of MLH1 in tumours that are microsatellite-unstable.
Application
Dilution: IHC: 1:50-1:200
Buffer Composition: Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
Buffer Composition: Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of Human colon tissue sections labeling MLH1 with IHC409-100.
Storage
Store at -20°C. Stable for one year from the date of shipment.
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